Data Catalog

This data collection documents all cases of military intervention across international boundaries by regular armed forces of independent states in the regions of Europe, the Americas (and Caribbean), Asia and the Pacific, Sub-Saharan Africa, and the Middle East/North Africa. Military interventions are defined operationally in this collection as the movement of regular troops or forces (airborne, seaborne, shelling, etc.) of one country into the territory or territorial waters of another country, or forceful military action by troops already stationed by one country inside another, in the context of some political issue or dispute. The study seeks to identify politically important actions which interpose a state directly into the conflict patterns occurring in another state, and which conceivably involve a breach of the sovereignty of the target state (albeit by invitation in some cases). The collection identifies intervener and target countries and specifies the starting and ending dates of the intervention. A series of potential interests in or motives for intervention are presented, including effects on the target's domestic disputes, foreign or domestic policies, and efforts to protect social factions in the target, to attack rebels in sanctuaries across borders ("hot pursuit"), to protect or enhance economic/resource interests, to protect military or diplomatic facilities, to save lives, or to affect regional power balances and strategic relations. Information is provided on the direction of the intervention, i.e., to support or oppose the target government, to support or oppose opposition groups in the target, or to support or oppose third-party governments or opposition groups. Other variables show the degree of prior intervention, the alliance or treaty relationship between intervener and target, prior colonial status, prior intervention, and measures of intervener and target power size. A series of intensity measures, such as battle-related casualties, is also included. For each type of incursion, by land, sea, or air, an ordinal scale of involvement is presented, ranging from minor engagement such as evacuation, to patrols, acts of intimidation, and actual firing, shelling, or bombing. Finally, contiguity information is provided to indicate both whether intervener and target are geographically contiguous, and whether the intervention was launched from contiguous territory.

Discoidin domain receptor 1 (DDR1) is a collagen-activated receptor tyrosine kinase extensively implicated in diseases such as cancer, atherosclerosis and fibrosis. Multiple preclinical studies, performed using either a gene deletion or a gene silencing approaches, have shown this receptor being a major driver target of fibrosis and glomerulosclerosis. The present study investigated the role and relevance of DDR1 in human crescentic glomerulonephritis (GN). Detailed DDR1 expression was first characterized in detail in human GN biopsies using a novel selective anti-DDR1 antibody using immunohistochemistry. Subsequently the protective role of DDR1 was investigated using a highly selective, novel, small molecule inhibitor in a nephrotoxic serum (NTS) GN model in a prophylactic regime and in the NEP25 GN mouse model using a therapeutic intervention regime.