Description: Proteomics data from a study on whether mercury exposure alters B cell responsiveness to self-antigens by interfering with B cell receptor (BCR) signal transduction. These data show the effects of mercury on the protein tyrosine kinase SYK, a critical protein involved in regulation of the BCR signaling pathway. The raw data for quantitation of SYK phosphorylation status of selected sites were obtained using multiple reaction monitoring (MRM) on a TSQ triple quadrupole mass spectrometer.
Timeframe: 2017 - 2017

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Access Restrictions: Free to all
Access Instructions: Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Associated Publications: Caruso, J. A., Carruthers, N., Shin, N., Gill, R., Stemmer, P. M., & Rosenspire, A. (2017). Mercury alters endogenous phosphorylation profiles of SYK in murine B cells. BMC immunology, 18(1), 37. doi:10.1186/s12865-017-0221-0
Data Type: Genetic/Omic
Equipment Used: TSQ triple quadrupole mass spectrometer
Dataset Format(s): XLS
Dataset Size: 10.4 GB

Grant Support: P30 ES020957/NIH Center Grant

P30 CA 022453/NIH Cancer Center Support Grant

S10 OD 010700/NIH Shared Instrumentation Grant

Data Catalog

Data from "Mercury alters endogenous phosphorylation profiles of SYK in murine B cells"
WSU Dataset